Brian Carlson, Ph.D. Research Scientist I Computational Bioengineering Group Biotechnology and Bioengineering Center 8701 Watertown Plank Road Milwaukee, WI 53226-0509 (414)-955-4822 (414)-955-6568(Fax) Email: becarlson@mcw.edu

Education

• Ph.D. Mechanical Engineering December 2001 University of California at Berkeley
  Dissertation: Numerical simulation of sickle cell blood flow in the transverse arteriole-capillary microvasculature
• B.S. Mechanical Engineering May 1986 University of California at Berkeley

Research Interests

• Theoretical modeling of acute vascular regulatory mechanisms in the microvasculature
• Modeling of human embryonic stem cell-derived cardiomyocyte electrophysiology
• Characterization of self-renewal and differentiation into cardiomyocytes of embryonic stem cells using pathway modeling techniques
• Sarcomere mechanics and diffusion of cytosolic proteins in skeletal muscle myofibrils
• Multiscale modeling and semi-automated model merging in the cardovasculature

Publications

• Carlson BE, Arciero JC, Secomb TW. Theoretical model of blood flow autoregulation: Roles of myogenic, shear-dependent and metabolic responses. American Journal of Physiology: Heart and Circulatory Physiology 295:H1572-H1579, 2008
• Arciero JC, Carlson BE, Secomb TW. Theoretical model of metabolic blood flow regulation: Roles of ATP release by red blood cells and conducted responses. American Journal of Physiology: Heart and Circulatory Physiology, 295:H1562-H1571, 2008
• Carlson BE, Anderson JC, Raymond GM, Dash RK and Bassingthwiaghte JB. Modeling oxygen and carbon dioxide transport and exchange using a closed loop cardiovascular system. Advances in Experimental Medicine and Biology: Oxygen Transport to Tissue XXIX 614:353-360, 2008
• Gennari JH, Neal ML, Carlson BE and Cook DL. Integration of multi-scale biosimulation models via light-weight semantics. Pacific Symposium on Biocomputing 13:414-425, 2008
• Carlson BE and Secomb TW. A theoretical model for the myogenic response based on the length-tension characteristics of vascular smooth muscle. Microcirculation 12:327-338, 2005.
• Berger SA and Carlson BE. Sickle cell blood flow in the microcirculation. Proceedings of the 26th Annual International Conference of the IEEE EMB 2:5057-5060, 2004.

Published Abstracts

• Carlson BE, Wilson GF, Zhang J, Kamp TJ and Beard DA, Characterization of human embryonic stem cell-derived cardiomyocyte action potentials and channel conductances using theoretical model, Biophysical Journal, 96:664a, 2009
• Carlson BE, Vigoreaux JO and Maughan DW. A theoretical model of the diffusion of glycolytic enzymes and other cytosolic proteins from rabbit skinned muscle fibers. FASEB Journal 22:962.31, 2008
• Bassingthwaighte JB and Carlson BE. Multiscale modeling of cardiac cellular energetics. Proceedings of the 8th World Congress for Microcirculation, August 2007
• Arciero JC, Carlson BE, Secomb TW. Roles of oxygen-dependent ATP release by red blood cells and conducted responses in metabolic regulation of blood flow. FASEB Journal 21:A479-A479, 2007
• Secomb TW, Carlson BE Simulation of flow regulation: Contributions of myogenic and shear-dependent vascular responses. Journal of Vascular Research 43:42-42, 2006
• Carlson BE, Secomb TW. Contributions of myogenic and shear responses to vascular regulation analyzed using a representative-segment vascular network model. FASEB Journal 20:A278-A278, 2006
• Carlson BE, Secomb TW. A theoretical model for the myogenic response based on the mechanics of vascular smooth muscle. FASEB Journal 18:A629-A629, 2004
• Carlson BE, Berger SA. Numerical simulation of sickle cell blood flow in the transverse arteriole-capillary network. FASEB Journal 17:A126-A126, 2003

Invited Presentations

• "A Theoretical Model of Sickle Cell Blood Flow in Microvascular Networks" Microvascular Networks session at Biomedical Engineering Society Conference Los Angeles, California, September 2007.
• "The Incorporation of Microcirculatory Regulatory Responses into and Application of Multiscale Modeling Techniques to Closed Loop Cardiovascular Models" Virtual Human Seminar Series University of Washington, Seattle, Washington, May 2007
• "Modeling the Diffusion of Cytosolic Proteins from Rabbit Skinned Muscle Fibers" 3rd Annual Bioengineering Cardiovascular Training Grant Symposium University of Washington, Seattle, Washington, May 2007
• "Computational Modeling of Microvascular Blood Flow Regulation Incorporating Myogenic and Shear-dependent Responses" Microcirculatory Society Young Investigators Symposium at Experimental Biology Conference Washington D.C., April 2007.
• "Structural Adaptation in the Vasculature: Remodeling Response to Chronic Local Conditions" Mini-symposium on Extracorporeal Shock Wave Treatment: Angiogenesis, Micro-vascular Remodeling and Wound Healing, University of Washington Medical Center, Seattle, Washington, Feburary 2006
• "Vascular Mechanics and Modeling in the Circulatory System" Biomechanics Seminar series: ME 598, University of Washington, Seattle, Washington, November 2005
• "Autoregulation of Blood Flow: Analysis of Competing Effects of Myogenic And Shear-dependent Vascular Responses" Joint Microcirculatory/British Microcirculatory Society Conference, University of New Hampshire, Durham, New Hampshire, September 2005

Honors and Affiliations

• University of Washington Bioengineering Cardiovascular Training Grant Postdoctoral Fellow, September 2006 – September 2007
• NSF Integrative Gradate Education and Research Traineeship (IGERT) Postdoctoral Fellow in Applied Mathematics, July 2002 – July 2004
• Member: Microcirculatory Society, November 2005 – present
• Member: Biomedical Engineering Society, September 2007 – present
• Member: Biophysical Society, September 2008 – present