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Analysis of Cardiac Mitochondrial Na+/Ca2+ Exchanger Kinetics with a Biophysical Model of Mitochondrial Ca2+ Handing
Suggests a 3:1 Stoichiometry

 

Ranjan K. Dash and Daniel A. Beard

Biotechnology and Bioengineering Center and Department of Physiology,
Medical College of Wisconsin, Milwaukee, WI-53226

 

Address correspondence to: Daniel A. Beard, Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, Phone: (414) 955-5752, Email: dbeard@mcw.edu

 

Key words: Mathematical modeling; Computer simulation; Mitochondria; Energy metabolism; Oxidative phosphorylation; Calcium handling; Na+/Ca2+ exchanger stoichiometry.
Computational Bioengineering Group, Biotechnology & Bioengineering Center
Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226