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Population-Based Analysis of Methadone Distribution and Metabolism Using an Age-Dependent Physiologically Based Pharmacokinetic Model

1Feng Yang, 2Xianping Tong, 3D. Gail McCarver,
3Ronald N. Hines and 1Daniel A. Beard

1Biotechnology and Bioengineering Center, Department of Physiology,
Medical College of Wisconsin
2Department of Computer Science, University of Montana
3Departments of Pediatrics and Pharmacology/Toxicology,
Medical College of Wisconsin

 

Address correspondence to: Daniel A. Beard, Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, Phone: (414) 456-5752, Email: dbeard@mcw.edu

Key words: PBPK, age-dependent, methadone, population study, pharmacokinetics, children
Computational Bioengineering Group, Biotechnology & Bioengineering Center
Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226