Fan Wu, Ph.D. Postdoctoral Fellow Computational Bioengineering Group Biotechnology and Bioengineering Center 8701 Watertown Plank Road Milwaukee, WI 53226-0509 (414)-955-2488 (414)-955-6568 (Fax) Email: fwu@mcw.edu

Education:

• Ph.D., Chemical Engineering, September 2002 to December 2005, University of New Hampshire.
  Dissertation: Nonlinear Dynamics of Blood Flow in Simple Microvascular Networks
• M.S., Chemical Engineering, September 1999 to July 2002, East China University of Science and Technology.
• B.S., Chemical Engineering, September 1995 to July 1999, East China University of Science and Technology.

Areas of Specialization:

Mathematical analysis and computational modeling of complex physiological and biological systems, Mass transport and metabolism energetics in cardiac tissue and skeletal muscle, Nonlinear dynamics of microvascular blood flow.

Selected Publications

• Fan Wu, Jianyi Zhang, and Daniel A. Beard. Experimentally observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism. Proceedings of the National Academy of Sciences 106(17):7143-7148, 2009.
• Joep Vanlier, Fan Wu, Feng Qi, Kalyan C. Vinnakota, Yuan Han, Ranjan K. Dash, and Daniel A. Beard. BISEN: Biochemical Simulation Environment. Bioinformatics 25(6):836-837, 2009.
• Fan Wu and Daniel A. Beard. Roles of the creatine kinase system and myoglobin in maintaining energetic state in the working heart. BMC Systems Biology 3(1):22, 2009.
• Fan Wu, Eric Y. Zhang, Jianyi Zhang, Rober J. Bache, and Daniel A. Beard. Phosphate Metabolite Concentrations and ATP Hydrolysis Potential in Normal and Ischemic Hearts. Journal of Physiology 586:4193-4208, 2008.
• Fan Wu, Feng Yang, Kalyan C. Vinnakota, and Daniel A. Beard. Computer Modeling of Mitochondrial Tricarboxylic Acid Cycle, Oxidative Phosphorylation, Metabolite Transport, and Electrophysiology. Journal of Biological Chemistry, 282(34):24525-24537, 2007.
• Fan Wu, Jereon A. Jeneson, and Daniel A. Beard. Oxidative ATP synthesis in skeletal muscle is controlled by substrate feedback. American Journal of Physiology – Cell Physiology, 292(1):C115-24, 2007.
• Russell T. Carr, John B. Geddes, Fan Wu. Oscillations in a simple microvascular network. Annals of Biomedical Engineering, 33(6):764-771, 2005.

Review Articles/Book Chapters

• Kalyan C. Vinnakota, Fan Wu, Martin J. Kushmerick, and Daniel A. Beard. Multiple Ion Binding Equilibria, Reaction Kinetics and Thermodynamics in Dynamic Models of Biochemical Pathways. Methods in Enzymology, 454:29-68, 2009.
• Daniel A. Beard, Fan Wu, Marco E. Cabrera, and Ranjan K. Dash. Modeling of cellular metabolism and microcirculatory transport. Microcirculation 15:777-793, 2008.

Selected Oral Presentations

• Fan Wu, Jianyi Zhang, and Daniel A. Beard. Computational analysis of cardiac energetics in failing hearts. 2009 SIAM Annual Meeting, Denver, CO, July 2009 (upcoming).
• Fan Wu, Jianyi Zhang, and Daniel A. Beard. Emergent Critical Phenomena in the Evolution of Heart Failure. Experimental Biology 2009, New Orleans, LA, April 2009.
• Fan Wu and Daniel A. Beard. Integrated Modeling of Cellular Energetics and Substrate Transport to Analyze Data on Cardiac Tissue. Microcirculatory Society Young Investigator Symposium, Experimental Biology 2007, Washington DC, May 2007.

Journal/Conference Service

• 2007 – Present, Reviewer for international scientific journals, including Annals of Biomedical Engineering, PLoS One, and Physiological Genomics
• 2009 – Present, Associate Faculty Member of Faculty 1000 Biology
• 2009, Reviewer for 31^st Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Memberships:

• 2007 - Present, The Microcirculation Society, Inc.
• 2007 - Present, The Biomedical Engineering Society
• 2009 - Present, The American Physiological Society

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