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Dr. Kalyan Chakravarthy Vinnakota

 

Kalyan Chakravarthy Vinnakota, Ph.D.
Postdoctoral Fellow

Computational Bioengineering Group
Biotechnology and Bioengineering Center
8701 Watertown Plank Road
Milwaukee, WI 53226-0509
(414)-955-5764
(414)-955-6568 (Fax)
Email: kvinnakota@mcw.edu

Education

  • Ph.D., Bioengineering, University of Washington, 2006
    Dissertation Title: pH Dynamics, Glycogenolysis and Phosphoenergetics in Isolated Cell Free Reconstituted Systems and in Mouse Skeletal Muscle
  • B.E., Biomedical Engineering, Osmania University, India , 2001

Research Interests

  • Thermodynamics and kinetics of biochemical systems
  • Muscle metabolism in physiological and pathophysiological states
  • Physiological systems modeling

Honors

  • 2001, Ranked first in the graduating class in Biomedical Engineering, Osmania University
  • 2004 - 2005, American Heart Association (Pacific Mountain Affiliate) Predoctoral Fellowship Award
  • 2004, American Heart Association (Pacific Mountain Affiliate) Outstanding Predoctoral Fellow Award

Abstracts

  • Vinnakota KC, Lambeth MJ, Kushmerick MJ, and Bassingthwaighte JB. Modeling the Energy Metabolism of the Cardiac Myocytes. Nippon Shinden Gakkai Gakujutsu Shukai Puroguramu Shorokushu 19: 367, 2002.
  • Vinnakota KC and Bassingthwaighte JB. Anatomical basis for modeling cardiac metabolic functions. Faseb Journal 17: A555-A555, 2003.
  • Bassingthwaighte JB, Vinnakota K, and Raymond GR. Morphometric substrate for modeling cardiac function. Faseb Journal 17: A774-A774, 2003.
  • Vinnakota KC, Kemp ML, and Kushmerick MJ. Dynamics of pH changes and phosphoenergetics in mouse skeletal muscle during transient anoxia are modeled by physical chemical principles. In: XXXV International congress of Physiological Sciences/Experimental Biology 2005. San Diego, 2005.
  • Vinnakota KC and Kushmerick MJ. A computational model of dynamics of pH, phosphoenergeties and glycogenolysis in mouse skeletal muscle: acidosis does not inhibit resting glycogenolysis. Faseb Journal 21: A1282-A1282, 2007.
  • Vinnakota KC, Mitchell DA, Beard DA, Wakatsuki T, and Deschenes RJ. Diffusion and Exchange Kinetics of Prenylated and Acylated GFP-Ras2 in Saccharomyces cerevisiae Using Fluorescence Recovery After Photobleaching. In: ASCB 47th Annual Meeting. Washington, DC, 2007.
  • Sedlic F, Vinnakota KC, Wakatsuki T, Bienengraeber M, and Bosnjak Z. Measurement of NAD(P)H and Flavoprotein Autofluorescence in Intact Cardiomyocyte to Determine Effects of Isoflurane on Mitochondrial Bioenergetics. In: ASCB 47th Annual Meeting. Washington, DC, 2007.
  • Haumann J, Patel, R, Aldakkak M, Rhodes SS, Vinnakota KC, Dash RK, Camara AKS, Beard DA, Stowe DF. ADP and CCCP–induced increases in mitochondrial free Ca2+: greater contribution of matrix Ca2+ buffering by ATP/ADP. FASEB J. 2008 22:756.6
  • Dash RK, Haumann J, Patel R, Aldakkak M, Rhodes SS, Camara AKS, Stowe DF, Vinnakota KC, Beard DA. Regulation of mitochondrial free Ca2+ by metabolite and pH dependent Ca2+ buffering in the matrix: analysis by a computational model of mitochondrial Ca2+ handling. FASEB J. 2008 22:756.7

Peer-reviewed publications

  • Vinnakota KC and Bassingthwaighte JB. Myocardial density and composition: a basis for calculating intracellular metabolite concentrations. Am J Physiol Heart Circ Physiol 286: H1742-1749, 2004.
  • Bassingthwaighte JB and Vinnakota KC. The computational integrated myocyte: a view into the virtual heart. Ann N Y Acad Sci 1015: 391-404, 2004.
  • Vinnakota K, Kemp ML, and Kushmerick MJ. Dynamics of Muscle Glycogenolysis Modeled with pH Time Course Computation and pH-Dependent Reaction Equilibria and Enzyme Kinetics. Biophys J 91: 1264-1287, 2006.
  • Wu F, Yang F, Vinnakota KC, and Beard DA. Computer modeling of mitochondrial tricarboxylic acid cycle, oxidative phosphorylation, metabolite transport, and electrophysiology. J Biol Chem 282: 24525-24537, 2007.
  • Beard DA, Vinnakota KC, and Wu F. Detailed enzyme kinetics in terms of biochemical species: study of citrate synthase. PLoS ONE 3: e1825, 2008.
  • Vinnakota KC, Wu F, Kushmerick MJ, and Beard DA. Multiple Ion Binding Equilibria, Reaction Kinetics and Thermodynamics in Dynamic Models of Biochemical Pathways. Methods  Enzymol., 2008. (submitted)
  • Vinnakota KC and Kushmerick MJ. Simulations of dynamics of pH, phosphoenergetics and flux of glycogenolysis in mouse EDL and SOL muscles. J Physiol, 2008. (submitted)
  • Vinnakota KC, Mitchell DA, Beard DA, Wakatsuki T, and Deschenes RJ. Diffusion of GFP-Ras2 in Saccharomyces cerevisiae Using Fluorescence Recovery After Photobleaching. Biophys J, 2008. (in preparation)

Conference proceedings