In vivo experiments are performed using techniques of Positron Emission Tomography, Magnetic Resonance Imaging and spectroscopy to measure changes in blood flow and metabolism in patients and animal models of disease as an aid to understanding basic mechanisms. Unique animal models produced with the aid of genomic manipulation are used in these experiments in an attempt to connect genes with cardiovascular functions. Data from our laboratory is analyzed with the aid of mathematical and computer models that we have developed based on morphological and experimental data. These models have proven to be extremely valuable in understanding the complex signals that cause changes in the circulation in response to normal and disease processes. Publications of Dr. Greene Lab
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In a broad sense, our laboratory is attempting to understand fundamental principles of cardiovascular regulation and disease. Our research is highly collaborative and spans the areas of molecular and cellular biology, genetics, proteomics, technology development and microcirculatory experiments. Studies in the laboratory focus on mechanisms of blood vessel growth and regression as well as the control of blood flow to tissues such as skeletal muscle and brain. Measurements of gene and protein expression, receptor numbers, oxygen transport, local blood flow, and microvascular density are used to assess the ability of the cardiovascular microcirculatory network to meet the needs of the tissue.